Gerald A. Zsido II1, Julio Chirinos2, Larry Dougherty3, Kevin Koomalsingh4, James J. Pilla2,4, Walter RT Witschey1,4, Hee Kwon Song2, Joseph H. Gorman III4, Robert C. Gorman4, Ravinder Reddy1
1Radiology, University of Pennsylvania, Center for Magnetic Resonance and Optical Imaging, Philadelphia, PA, United States; 2University of Pennsylvania, Division of Cardiovascular Medicine, Philadelphia, PA, United States; 3Radiology, University of Pennsylvania, Philadelphia, PA, United States; 4Surgery, University of Pennsylvania, Philadelphia, PA, United States
A technique for rapid quantification of 1H relaxation times in the human myocardium during systole and diastole was developed. The technique makes use of a T1ρ spin locking pulse cluster, followed by a short, multiecho, radial acquisition, from which k-space-weighted image contrast reconstruction is performed. An 8-fold acceleration of data acquisition was obtained in vivo, compared to a similar set of fully sampled data. In 3 subjects, each scanned 4 times; a significant difference between left ventricular systolic and diastolic relaxation times was measured.