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Abstract #3734

Saturation Correction of Dynamic Contrast Enhanced MRI Uptake Curves for Quantitative Myocardial Blood Flow Measurements Using an Assumed T1 for Blood

John David Biglands1, Abdulghani Larghat1, Sven Plein1, David L. Buckley1, Michael Jerosch-Herold2, Derek Magee3, Roger Boyle3, Aleksandra Radjenovic1

1School of Medicine, University of Leeds, Leeds, UK, United Kingdom; 2Radiology, Brigham and Womens Hospital, Boston, MA, United States; 3School of Computing, University of Leeds, Leeds, United Kingdom

Dynamic contrast enhanced magnetic resonance imaging of the myocardium using sufficiently high doses to be clinically useful generates uptake curves that require correction for signal saturation effects before they can be used for myocardial blood flow (MBF) estimation. Such corrections require knowledge of the native T1 of the blood and myocardium. This abstract shows that using an assumed blood T1 enables saturation correction of typical clinical datasets without the need for time consuming T1 measurements. MBF estimates from nine patients were consistent with literature values and were shown to be robust to variations in the assumed T1 of blood.