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Abstract #3966

Diffusion Properties of Cortical Layers in Fixed Human Brain Tissue Investigated with High-Resolution STEAM

Ana-Maria Oros-Peusquens1, Arlad Roebroeck2, Oleg Posnansky1, N Jon Shah1,2

1Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Juelich GmbH, Juelich, Germany; 2Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany

MRI of fixed tissue can be performed with very high resolution since measurement time is not a major constraint. Here, we use STEAM diffusion to overcome EPI-related problems (poor resolution, distortions, signal drop out) at 9.4T. We investigate fixed tissue samples from the occipital lobe (visual cortex) and temporal lobe (auditory cortex) with a voxel size of 80nl (resolution of 0.3x0.3x0.8mm). Cortical layer structure is observed in the ADC and FA maps. Fibre tracks from the stria of Gennari, from adjacent white matter and fibres emerging from the grey matter joining the regular tracts of the white matter are investigated.