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Abstract #3967

Nanotubular Superparamagnetic Probes as Contrast Agents for Diffusion Tensor Magnetic Resonance Imaging

Viviana Negri1, Arisbel Cerpa2, Laura Nieto3, Pilar Lopez-Larrubia3, Sebastian Cerdan3, Paloma Ballesteros4

1Organic Synthesis and Molecular Imaging Laboratory, UNED-CSIC Unit, Madrid, Spain; 2Universidad Europea de Madrid, Madrid, Spain; 3Animal Models of Human Disease, IIBM-CSIC, Madrid, Spain; 4Orghanic Synthesis and Molecular Imaging Laboratory, UNED-CSIC Unit, Madrid, Spain

Single Walled Carbon Nanotubes (SWNTs) prepared by Chemical Vapor Deposition, oxidized with nitric acid during 48h, depicted 100-200 nm length and contained the paramagnetic metals (17% Ni, 4% Y). Orthogonal water ADC measurements performed in a suspension of SWNTs in sodium dodecylbenzenesulfonate (2%), with the diffusion encoding gradient oriented in the H-F, L-R or A-P directions, showed significantly higher water ADCs in the H-F direction than in the perpendicular plane. These results suggest that ADC values of tissue water may be modified anisotropically using these preparations, opening a new perspective for contrast agents active in ADC weighted MRI.