Viviana
Negri1, Arisbel Cerpa2, Laura Nieto3, Pilar
Lopez-Larrubia3, Sebastian Cerdan3, Paloma Ballesteros4
1Organic Synthesis and Molecular
Imaging Laboratory, UNED-CSIC Unit, Madrid, Spain; 2Universidad
Europea de Madrid, Madrid, Spain; 3Animal Models of Human Disease,
IIBM-CSIC, Madrid, Spain; 4Orghanic Synthesis and Molecular
Imaging Laboratory, UNED-CSIC Unit, Madrid, Spain
Single
Walled Carbon Nanotubes (SWNTs) prepared by Chemical Vapor Deposition, oxidized
with nitric acid during 48h, depicted 100-200 nm length and contained the
paramagnetic metals (17% Ni, 4% Y). Orthogonal water ADC measurements
performed in a suspension of SWNTs in sodium dodecylbenzenesulfonate (2%),
with the diffusion encoding gradient oriented in the H-F, L-R or A-P
directions, showed significantly
higher water ADCs in the H-F direction than in the perpendicular plane. These results suggest that ADC values of
tissue water may be modified anisotropically using these preparations,
opening a new perspective for contrast agents active in ADC weighted MRI.
Keywords