Tristan Anselm Kuder1, Bram Stieltjes, Amir Moussavi1, Frederik Bernd Laun1
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
The diffusion kurtosis is obtained by fitting a polynomial to the logarithmic diffusion weighted signal acquired at different b-values. The aim of this study was to evaluate factors influencing the measured kurtosis. A strong dependence on the maximum b-value and the fitting polynomial was found. The cubic fit does not eliminate the dependence on the maximum b-value and causes a larger uncertainty in the measured kurtosis values compared to the quadratic fit. Thus, the quadratic fit is preferable. Fitting the Diffusion Kurtosis Tensor with 15 directions is unstable and at least 30 gradient directions should be used.