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Abstract #3983

Dexterity and Age Relate Differently to White Matter Organization in Cervical Spinal Cord in Healthy Subjects

Pvel Lindberg1, Antoine Feydy2, Marc A. Maier3

1Radiology B, Hopital Cochin, Paris, France; 2Radiology B, Hpital Cochin, Paris, France; 3LNRS, Universite Paris Descartes, Paris, France

We hypothesized that spinal white matter organization relates to the level of dexterity in healthy subjects. Spinal white matter was analyzed using DTI and related to a precision grip tracking task. FA was lower in subjects with high tracking error and decreased with age. The closest relation between FA and tracking error was found in the lateral spinal cord whereas FA of the medial spinal cord correlated with age. The results suggest (i) a functionally relevant specialization of lateral spinal cord white matter and (ii) an increased sensitivity to age-related decline in medial spinal cord white matter in healthy subjects.