Emma Claire Robinson1,2, Fani Deligianni1,2,
Alexander Hammers2, Daniel Rueckert1, A. David Edwards2
1Department of Computing, Imperial
College, London, United Kingdom; 2Clinical Sciences Centre,
Imperial College, London, United Kingdom
This
abstract presents a study of fractional anisotropy (FA) variability in tracts
passing from anterior to posterior regions of the brain during healthy
ageing. Tracts are propagated in a common-co-ordinate space using a
probabilistic white matter atlas. This is constructed by transforming
uncertainty distributions on the principle diffusion directions for each
subject to a common co-ordinate space and combining to generate a
distribution for the population. FA is compared all voxels along the tract
using permutation testing. Studying tracts in this way allows direct
visualisation of FA changes along the full length of the tract
Keywords