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Abstract #3985

Development of a WM Atlas Based on Anatomical Connectivity Mapping

Mara Cercignani1, Karl Embleton2, Geoff J. M. Parker3, Marco Bozzali1

1Neuorimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 2Cognition and Cognitive Neuroscience Group, School of Psychological Sciences, University of Manchester, United Kingdom; 3Imaging Science & Biomedical Engineering and the Biomedical Imaging Institute, University of Manchester, United Kingdom

Anatomical connectivity mapping (ACM) is obtained by initiating tractography streamlines from all parenchymal voxels, and counting the number of streamlines passing through each voxel of the brain, thus highlighting WM structures strongly connected to the rest of the brain. DTI data from 10 subjects were normalised and averaged to compute the mean tensor, from which FA and ACM were obtained. Colour-coded maps of principal eigenvector, modulated by ACM are displayed. Several structures typically visible on colour-coded FA maps are visible also on ACM. Many other structures, however, can be seen more clearly and with greater resolution on the ACM images