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Abstract #4033

Effect of Diffusion Time and B-Value on Quantitative DTI

Edward S. Hui1,2, Steve H. Fung2,3, Ed X. Wu1,4

1Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong, Hong Kong; 2Department of Radiology Research, The Methodist Hospital Research Institute, Houston, TX, United States; 3Department of Radiology, Weill Medical College of Cornell University, New York, United States; 4Department of Electrical & Electronic Engineering, The University of Hong Kong, Hong Kong, Hong Kong

Diffusion-weighted (DW) signal attenuation depends on not only the diffusion gradient strength but also the separation between the two diffusion gradients (i.e., diffusion time Δ). In this study, the effect of Δ and diffusion weighting factor b-value was examined and documented for conventional DTI by acquiring DW signals with various b-values at different Δ from normal adult rat brains in vivo.