Miia Pitkonen1, Aysan Durukan2,
Eric Pedrono3, Ivan Marinkovic2, Turgut Tatlisumak2,
Usama Abo-Ramadan4
1Biomedicum Helsinki, Experimental MRI
laboratory , Helsinki,
Finland; 2Department of Neurology, Helsinki University Central
Hospital, Helsinki, Finland; 3Biomedicum Helsinki, Experimental
MRI Laboratory, Helsinki, Finland; 4Biomedicum Helsinki,
Experimental MRI Laboratory, Helsinki, Finland
Diffusion
tensor imaging can approximates the linear, planar, and tubular tensor using
CL, CP, and CS. We want to characterize the evolvement of these indices
following brain ischemia. We followed the evolvement of these indices in 3
cortex, subcortex, and corpus callosum. Following brain ischemia, no such
systematic approach over an extended period of time, with CL, CP, and CS, has
not yet been reported. Wistar rats were subjected to focal cerebral ischemia
by transient suture occlusion (n = 9). They were imaged in the hyperacute (2
and 3.5 hours), acute (1, 2, and 3 days), subacute (4 days, 1, and 2 week),
and in the chronic phase (4, 6, and 8 weeks) after the MCAO. The MRI
measurements were performed with a 4.7 T MR Scanner. Following acute
ischemia, indices indicated damage in the neuronal cell bodies and in the
chronic ischemic tissue possible recovery.