Abstract #4055

Co-Registration of DTI Tractography with Gd-Enhanced T1 Imaging in Evaluation of CED Studies in the Rhesus Macaque

Elizabeth Zakszewski^1,2, Nagesh Adluru¹, Marina Emborg,²³, Andrew L. Alexander^1,2

¹Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, WI, United States; ²Dept. of Medical Physics, University of Wisconsin, Madison, WI, United States; ³Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, United States

We use landmark-based registration methods to co-register diffusion tensor images with T1-Weighted images of the same animal taken during a Convection Enhanced Delivery (CED) study to the rhesus putamen. We then use the area of Gd-enhanced infusate at various time points as seeds to perform white-matter tractography, with the intent of visually evaluating the accuracy of the infusion.