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Abstract #4072

Cerebral Autoregulation Impairment Measured at the Brain Tissue Level with Arterial Spin Labeling MRI in Patients with a Symptomatic Carotid Artery Stenosis

Reinoud Pieter Harmen Bokkers1, Matthias J.P. van Osch2, H Bart van der Worp3, Gert J. de Borst4, Willem P Th M Mali1, Jeroen Hendrikse1

1Department of Radiology, UMCU, Utrecht, Netherlands; 2Department of Radiology, LUMC, Leiden, Netherlands; 3Department of Neurology, UMCU, Utrecht, Netherlands; 4Department of Vascular Surgery, UMCU, Utrecht, Netherlands

Patients with a stenosis of the internal carotid artery have a high risk of ischemic stroke. In these patients, impairment of the vasodilatory capacity of the cerebral vasculature is an important measure of the degree of hemodynamic compromise. The aim of our study was to measure the cerebral autoregulatory status of the brain tissue supplied by the individual brain feeding arteries using arterial spin labeling MRI and to compare this to healthy controls. Our results show, that ASL is able to visualize and quantify the vasodilatory capacity in the flow territories of the major cerebral arteries at brain tissue level.