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Abstract #4078

Comparison of Reproducibility Between Continuous, Pulsed, and Pseudo-Continuous Arterial Spin Labeling

Yufen Chen1, Jiongjiong Wang1, Marc Korczykowski1, Maria Fernandez-Seara2, John A. Detre1

1Center of Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA, United States; 2Center for Applied Medical Research, University of Navarra, Pamplona, Navarra, Spain

Pseudo-continuous arterial spin labeling is a recent addition to the family of ASL methods that combines the high signal-to-noise ratio (SNR) of continuous methods and the lower duty cycle of pulsed methods. To date, no formal within- and across-session comparison between the methods has been performed. Here, we compare the reproducibility of three variants of ASL: continuous, pulsed and pseudo-continuous. Our results demonstrate that pCASL and PASL have the lowest degree of variations (~13%) in scans repeated after one week, pCASL also has higher temporal SNR, which makes it a favorable method for measuring cerebral blood flow.