Rajan Jain1, Hassan Bagher-Ebadian2,3, Jayant Narang1, Siamak Pourabdollah Nejad-Davarani2, Sona Sakesna1, Lonni Schultz4, Mohammad H. Asgari2, James R. Ewing2,3
1Radiology, Henry Ford Hospital, Detroit, MI, United States; 2Neurology, Henry Ford Hospital, Detroit, MI, United States; 3Physics, Oakland University, Rochester, MI, United States; 4Biostatistics and Research Epidemiology, Henry Ford Hospital, Detroit, MI, United States
In Patlak analysis, contrast agent transport is assumed to be unidirectional (from plasma space into extracellular extravascular space). Although this model has the advantage of simplicity, it is important to note that it will give inaccurate results when this assumption is incorrect as in leaky brain tumors. Using longer acquisition fit-times will probably yield overestimates of fV and underestimates of Ktrans in the leaky regions as these will fall into the non-linear part of the Patlak plot. Hence, understanding of the optimal fit-times as well as proper modeling used for Patlak analysis is important for measuring the physiologic parameters accurately.