Charles S. Springer, Jr. 1, William D.
Rooney1, Xin Li1
1Advanced Imaging Research Center,
Oregon Health & Science University, Portland, OR, United States
An
honored method for pharmacokinetic interpretation is the Patlak Plot the
popular linearization technique introduced over 25 years ago for graphical
tracer data analyses. In
(Dynamic-Contrast-Enhanced) DCE-MRI, the injected contrast reagent (CR) plays
the tracer role. However, there are
crucial differences between the molecular mechanisms underlying the detection
of tracers and CRs. This contribution
discusses how these differences impact the use of the Patlak Plot for the
analysis of DCE-MRI data.
Keywords