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Abstract #4091

The Patlak Plot in MRI Pharmacokinetic Analysis

Charles S. Springer, Jr. 1, William D. Rooney1, Xin Li1

1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States

An honored method for pharmacokinetic interpretation is the Patlak Plot the popular linearization technique introduced over 25 years ago for graphical tracer data analyses. In (Dynamic-Contrast-Enhanced) DCE-MRI, the injected contrast reagent (CR) plays the tracer role. However, there are crucial differences between the molecular mechanisms underlying the detection of tracers and CRs. This contribution discusses how these differences impact the use of the Patlak Plot for the analysis of DCE-MRI data.