Areen
Al.Bashir1,2, Gilda Hillman3, Meng Li2,
Yashwanth Katkur2, E. Mark Haacke1,2
1Department of Biomedical Engineeringt,
Wayne State University, Detroit, MI, United States; 2Department of
Radiology, Wayne State University, Detroit, MI, United States; 3Department
of Radiation Oncology, Wayne State University
DCE-MRI
has been routinely used to quantify the effectiveness of new anti-angiogenic
drugs on the tumor vasculature using Gd-DTPA as a contrast agent. However,
this quantification is not easy. DCE has a lot of parameters that make it a
very complex technique, such as finding AIF and choosing the pharmacokinetic
model. Hence, in this study, we introduced the new DCE parametric maps which
was calculated from Gd concentration, C(t), data. Regional analysis were
preformed on 4 groups of mice treated with different dose of the
anti-angiogenic drug, sunitinib, and the results compared. Our results
demonstrate that DCE parametric maps have the potential to quantify the
effect of new anti-angiogenic drugs on tumor and normal tissues. These
findings were confirmed with histological observations.
Keywords