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Abstract #4095

Introducing New DCE Parametric Maps to Quantify Vascular Changes Induced by the Anti-Angiogenic Drug Sunitinib

Areen Al.Bashir1,2, Gilda Hillman3, Meng Li2, Yashwanth Katkur2, E. Mark Haacke1,2

1Department of Biomedical Engineeringt, Wayne State University, Detroit, MI, United States; 2Department of Radiology, Wayne State University, Detroit, MI, United States; 3Department of Radiation Oncology, Wayne State University

DCE-MRI has been routinely used to quantify the effectiveness of new anti-angiogenic drugs on the tumor vasculature using Gd-DTPA as a contrast agent. However, this quantification is not easy. DCE has a lot of parameters that make it a very complex technique, such as finding AIF and choosing the pharmacokinetic model. Hence, in this study, we introduced the new DCE parametric maps which was calculated from Gd concentration, C(t), data. Regional analysis were preformed on 4 groups of mice treated with different dose of the anti-angiogenic drug, sunitinib, and the results compared. Our results demonstrate that DCE parametric maps have the potential to quantify the effect of new anti-angiogenic drugs on tumor and normal tissues. These findings were confirmed with histological observations.