Keiichi Kikuchi1, Shohei Kouno2, Hitoshi Miki1, Shogo Oda1, Teruhito Mochizuki1, Shiro Ohue2, Kenya Murase3
1Radiology, Ehime University, Toon City, Ehime, Japan; 2Neurosurgery, Ehime University, Toon City, Ehime, Japan; 3Medical Engineering, Osaka University, Suita, Osaka, Japan
We evaluated various tracer kinetics parameters of brain gliomas using combined DCE-MRI and DSC-MRI in one examination. The tracer kinetics parameters are high in grade IV gliomas; especially the K1 value has a significant correlation with MIB-1 and MVD. These parameters derived from DSC-MRI and DCE-MRI should be correlated with the tumor vascularity and/or tissue permeability, and will provide additional information for diagnosis and prediction prognosis. Our protocol, which can derive the various tracer kinetics parameters of brain tumors in one examination, will be a promising protocol to evaluate the characteristics of brain tumors.