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Abstract #4097

Quantitative Analysis of Perfusion Parameters in Osteoporotic Patients with Acute Vertebral Fracture Using Dynamic-Contrast-Enhanced MRI

Gerwin P. Schmidt1, Andreas Biffar, Steven P. Sourbron, Melvin D'Anastasi, Mike Notohamiprodjo, Maximilian F. Reiser, Andrea Baur-Melnyk

1Department of Radiology, University Hospitals Munich, Munich, Bavaria, Germany

The analysis of dynamic contrast-enhanced data provides reproducible quantitative perfusion parameters in healthy and pathologic bone marrow. Perfusion is strongly increased in acute osteoporotic fractures yielding areas of different perfusion parameters, potentially representing different sites of reactive and reparative process. Furthermore, perfusion parameter changes correlate with severity of osteoporosis and may serve as a tool to differentiate various stages of the disease.