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Abstract #4098

Qualitative and Quantitative Assessment of Osteosarcoma Treatment Response Using DCE-MRA

Junyu Guo1, Wilburn E. Reddick1

1Radiological Science, St Jude Children's Research Hospital, Memphis, TN, United States

A DCE-MRA method is presented to provide a new way of rendering DCE-MRI data, which greatly simplifies the process for the large volume of DCE-MRI data and enables qualitative and quantitative assessment of the treatment response. The qualitative DCE-MRA method provides a simple and quick way for a radiologist to make an overall assessment of tumor response to neoadjuvant chemotherapy. This method makes it potentially possible for a radiologist to identify a likely nonresponder. The quantitative measures were evaluated and the shape of plot curves of the two patients was consistent with that from direct observation of MIP images.