Meeting Banner
Abstract #4101

Nonlinear Partial Volume Effects in DCE-MRI

Matthias C. Schabel1, Edward V R DiBella1

1Radiology/Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, United States

In the presence of partial voxel blood volume, conventional quantitative methods of converting signal to concentration in DCE-MRI result in significant biases in pharmacokinetic parameter estimates. Direct modeling and nonlinear regression of signal dependence on concentration avoids these biases, giving accurate and unbiased parameter estimates.