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Abstract #4102

Non-Linear Contrast Agent Relaxivity and the Accuracy and Sensitivity of DCE MRI Measurements

Vishal Patil1, Glyn Johnson1

1Radiology, NYU School of Medicine, New York, United States

DCE MRI is increasingly used to determine the prognosis and diagnosis of various pathologies. The accuracy of DCE MRI parameter estimates is dependent on a variety of factors including the relationship between relaxivity and contrast agent concentration, C. Recent studies have demonstrated that relaxivity is not linearly dependent on C but is more accuratly described by a quadratic model. In this study we investigate the effect of neglecting non-linear components on DCE MRI parameter estimates derived using a Tofts/Kety model with both T1 and T2*-weighted protocols.