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Abstract #4108

A Method to Remove Large Blood Vessel Contribution in Brain Tumor Perfusion Imaging

Kelvin K. Wong1,2, Hui You3, Geoffrey S. Young3,4, Stephen TC Wong1,2

1Department of Radiology, The Methodist Hospital Research Institute, Houston, TX, United States; 2Department of Radiology, Weill Cornell Medical College, New York, United States; 3Department of Radiology, Brigham and Women's Hospital, Boston, MA, United States; 4Department of Radiology, Harvard Medical School, Boston, MA, United States

Regional cerebral blood volume is a useful marker for brain tumor evaluation. However, large blood vessels also contribute to high blood volume, which may have nothing to do with tumor angiogenesis. Prior studies focused on multi-parametric methods to remove a blood vessel which is complex to implement and have a lot of assumptions in the automatic identifications. We propose a simple method to identify the regions affect by large blood vessels using a blood flow map generated by a novel deconvolution technique and successfully identifies the blood vessel contribution in the tumor blood volume map.