Yen-Peng Liao1, Yi-Ying Wu2,
Yuan-Yu Hsu3, Yau-Yau Wai, 1,4, Ho-Ling Liu1,4
1Department of Medical Imaging and
Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; 2Department
of Radiology, Taichung Veterans General Hospital, Taiwan; 3Department
of Medical Imaging, Buddhist Tzu Chi General Hospital, Taipei, Taiwan; 4Division
of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan,
Taiwan
In
DSC-MRI, the leakage of contrast agent which results in additional T1 and T2*
relaxation effects in disrupted BBB causes the contamination of T2*-weighted
signal. The relative CBV (rCBV) may be
overestimated with uncorrected signal information. This phenomenon can be described with a
theoretical model considered T1 and T2* relaxation effects and the rCBV can
be corrected. Based on the model, the
T1 of pre-contrast tissue measurement was an essential parameter for
quantifying permeability surface area product (PS). This study provides a method for absolutely
quantification of PS. The results
showed comparable values to those in literatures.
Keywords