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Abstract #4109

Quantification of Vessel Permeability with Dynamic Susceptibility Contrast MRI

Yen-Peng Liao1, Yi-Ying Wu2, Yuan-Yu Hsu3, Yau-Yau Wai, 1,4, Ho-Ling Liu1,4

1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; 2Department of Radiology, Taichung Veterans General Hospital, Taiwan; 3Department of Medical Imaging, Buddhist Tzu Chi General Hospital, Taipei, Taiwan; 4Division of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Taoyuan, Taiwan

In DSC-MRI, the leakage of contrast agent which results in additional T1 and T2* relaxation effects in disrupted BBB causes the contamination of T2*-weighted signal. The relative CBV (rCBV) may be overestimated with uncorrected signal information. This phenomenon can be described with a theoretical model considered T1 and T2* relaxation effects and the rCBV can be corrected. Based on the model, the T1 of pre-contrast tissue measurement was an essential parameter for quantifying permeability surface area product (PS). This study provides a method for absolutely quantification of PS. The results showed comparable values to those in literatures.