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Abstract #4110

Assessment of the Vascularity of Glioblastoma Multiforme Using Alternate-Echo Multislice Perfusion-Weighted MRI with the First-Pass Pharmacokinetic Model

Tatsuya Yamamoto1, Hidemasa Uematsu1, Hiroaki Takeuchi2, Hirohiko Kimura1

1Department of Radiology, University of Fukui, Fukui, Japan; 2Department of Neurosurgery, University of Fukui, Fukui, Japan

T1 shortening effect due to the leakage of contrast agent causes underestimation of the tumor vascularity using single-echo perfusion-weighted MR imaging. On the other hand, T2* shortening due to contrast material present in the extravascular space causes overestimation. To incorporate the effects of the extravascular compartment containing contrast material residue, pharmacokinetic modeling with two compartments: the intravascular space; and the extravascular space: is required. We demonstrate here that the combination of an alternate-echo, single shot SPIRAL acquisition and first-pass pharmacokinetic model can correct for the T1 shortening effect, as well as for the T2* shortening in order to evaluate the exact tumor vascularity of enhancing glioblastoma multiforme.