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Abstract #4122

MRI-Based Temperature Analysis of Transcranial MRI-Guided Focused Ultrasound Surgery for Functional Neurosurgery

Nathan McDannold1, Beat Werner2, Daniel Jeanmonod3, Eyal Zadicario4, Rita Schmidt4, Ernst Martin2

1Radiology, Brigham & Women's Hospital/Harvard Medical School, Boston, MA, United States; 2MR-Center, University Childrens Hospital Zurich, Zurich, Switzerland; 3Department of Functional Neurosurgery, University Hospital Zurich, Zurich, Switzerland; 4InSightec, Ltd., Tirat Carmel, Israel

This work used MR temperature imaging (MRTI) to evaluate focal and skull-induced heating in nine patients treated for neuropathic pain in order to characterize the safety profile of a Transcranial MRI-guided Focused Ultrasound system. The ratio between focal and skull-induced heating was 11.3 using a conservative approach, approximately 2.7 times higher than in previous tests of an earlier ver-sion in glioblastoma patients, presumably due to improvements in the system, MRTI, and differences in target location. These results suggest an improved treatment window that can potentially increase the volume of the brain that can be safely targeted by the system.