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Abstract #4142

MR-Guided Trans-Perineal Cryoablation of Locally Recurrent Prostate Adenocarcinoma Following Radical Prostatectomy

David Arthur Woodrum1, Lance Mynderse2, Akira Kawashima1, Krzysztof Gorny1, Thomas Atwell1, Fred Mcphail2, Bradley Bolster3, Wesley Gilson3, Kimberly Amrami1, Haraldur Bjarnason1, Matthew Callstrom1

1Radiology, Mayo Clinic, Rochester, MN, United States; 2Urology, Mayo Clinic, Rochester, MN, United States; 3Siemens Medical Solutions, Inc.

Prostate cancer recurrence after definitive therapy can be as high as 25% after 15 years. Detection of these recurrences can be achieved using serial PSA coupled with dynamic contrast enhanced (DCE) MRI. Our hypothesis is MR-guided cryoablation can be used in the setting of prostate bed PAC recurrence to perform a precise image-guided focal ablation. Two patients with prior RRP and dynamic contrast enhancement(DCE) MRI abnormalities in the prostate bed were treated using MR-guided cryoablation. Both patients with recurrent prostate cancer in the prostate bed were successfully treated with MR-guided cryoablation. Immediate post-ablation DCE MRI demonstrated no definite residual tumor.