Abstract #4150

Mr Guided Transmyocardial Delivery of Hepatocyte Growth Factor Gene Into Infarct Scar with Established Remodelled Left Ventricle

Maythem Saeed¹, David Saloner¹, Phillip Ursell², Loi Do¹, Mark Wilson¹, Alastair J. Martin¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, Ca, United States; ²Pathology, University of California San Francisco, San Francisco, Ca, United States

It is unknown whether MR-guided transendocardial delivery of hepatocyte growth factor gene (HGF) is effective in ameliorating LV remodelling. XMR suite (x-ray cath-lab and a 1.5T MR scanner) for real-time imaging, transendocardial delivery and assessing the gene effects in swine with remodelled LV. Six MR sequences were used for evaluation of the efficacy of therapy. MR-guided transendocardial delivery of HGF a) ameliorated global function and 3D strain, b) activated perfusion, neovascularization and myogenesis in scar and c) reduced infarct. The combination of this therapy and XMR technique may be useful in patients with ischemic myocardium and cell loss (apoptosis).