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Abstract #4172

5T Micro-MRI of Macrophages in Obesity-Associated Inflammation: Feasibility Study

Marie Poirier-Quinot1, Alain Luciani2, Michael Levy3, Jean-Christophe Ginefri1, Nathalie Luciani3, Vanessa Devaux2, Sylvie Manin2, Eric Lancelot4, Luc Darrasse1, Claire Wilhelm3, Florence Gazeau3

1U2R2M - UMR 8081 CNRS/Univ Paris Sud, Orsay, France; 2INSERM U841, Hpital Henri Mondor, Crteil, France; 3UMR 7057 CNRS/Univ Paris - Diderot, France; 4Guerbet Recherche, Roissy, France

It has been recently shown that obesity-associated inflammation is related to the recruitment of pro-inflammatory macrophages. The present work investigates the feasibility to detect in-vivo macrophages in a murine model of obesity using magnetic resonance microscopy following systemic injection of a new kind of iron-oxide nanoparticles (USPIO). High-resolution 1.5 T MRI combined with a superconducting surface coil and an improved USPIO, for micrometric evaluation of fat tissue, appears to be an efficient way to detect macrophages related to fat inflammation. This approach for the follow-up of animals involved in therapeutic trials aimed at limiting fat inflammation has great potential.