Heechul Kim1,2, Piotr Walczak1,2,
Naser Muja1,2, James T. Campanelli3, Jeff W.M. Bulte1,2
1Russell H. Morgan Department of
Radiology and Radiological Science, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States; 2Cellular Imaging Section,
Institute for Cell Engineering, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States; 3Q Therapeutics, Inc.,
Salt Lake City, UT, United States
Magnetically
labeled human glial restricted precursor (hGRP) cells were transplanted and
tracked in a mouse model of multiple sclerosis. The clinical severity of EAE
was attenuated in hGRP-transplanted mice compared with controls. Hypointense
MRI signals were detected primarily in the ventricles after transplantation.
hGRP cell-treated mice showed a significant decrease in antigen-specific T
cell proliferation in response to MOG and concanavalin A, compared to control
mice. Based on the above results, we postulate that the signals generated
from transplanted GRP cells in the ventricle modulate the systemic immune
response.
Keywords