Hilary Hancock1, Eric M. Gold1,
Bobbi K. Lewis1, Melissa Smith1, Victor Frenkel1,
Joseph A. Frank1,2
1Radiology and Imaging Sciences, NIH,
Bethesda, MD, United States; 2National Institute of Biomedical
Imaging and Bioengineering, NIH, Bethesda, MD, United States
This
study investigated in vivo labeling of monocytes with SPIO/fluorescent 40nm
beads followed by Cellular MRI and fluorescent microscopy to determine the
effects of ablative or pulsed high intensity focused ultrasound (HIFU) in a
murine model. Pulsed HIFU exposures exhibited smaller regions of edema and
hypointense regions, confined to superficial muscle and dermis, on T2*W
images with smaller amounts of immune response within tissues compared to
ablated tissues.