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Abstract #4181

Pro-Survival Cocktail Improves Bone Marrow Stromal Cells (BMSC) Survival and Homing to Flank Tumors as Demonstrated by Cellular MRI

Aneeka Chaudhry1, Edyta Pawelczyk2, Eric Gold1, Bobbi K. Lewis1, Melissa Brown1, Arun Balakumaran3, Joseph A. Frank1,4

1Clinical Center, NIH, Bethesda, MD, United States; 2Federal Drug Administration, Bethesda, MD, United States; 3National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD, United States; 4National Institute of Biomedical Imaging and Bioengineering, NIH, Bethesda, MD, United States

In-vivo loss of implanted or infused cells is detrimental to stem cell therapies, as it undermines cell homing and therapeutic efficacy. This study aims to improve the homing and survival of FePro labeled bone marrow stromal cells via incubation with a cocktail of pro-survival and growth factors.