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Abstract #4185

In Vivo MRI Multicontrast Kinetic Analysis of the Uptake and Intracellular Trafficking of Paramagnetically Labeled Liposomes

Daniela Delli Castelli1, Enzo Terreno1, Walter Dastr1, Evelina Cittadino1, Francesco Mainini1, Elena Torres1, Michela Spadaro1, Silvio Aime1

1University of Torino, Turin, Italy

The multi-contrast ability of paramagnetically loaded liposomes have been exploited to get a better understanding of their uptake and intracellular trafficking in vivo in a tumor environment.In order to account for the observed MRI data, a kinetic model able to describe the underlying biological processes has been developed. The fit of the data provides a rough estimate of the kinetic constants for each process considered in the model.