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Abstract #4187

A Dose Dependent Inflammatory Cell Tracking by Micrometer-Sized Iron Oxide Particles-Enhanced MRI in Murine Myocardial Infarction Model

Yidong Yang1,2, Jimei Liu1, Yuhui Yang1, Tom C.-C. Hu1,2

1Department of Radiology, Medical College of Georgia, Augusta, GA, United States; 2Medical Physics Program, Georgia Institute of Technology, Atlanta, GA, United States

Inflammation plays a pivotal role in the cardiac remodeling process following myocardial infarction. Recently, it has been shown that inflammatory cells such as macrophages can be labeled with micrometer-sized iron oxide particles (MPIO) via systemic injection. After myocardial infarction, MPIO-labeled inflammatory-cell infiltration at MI sites can be monitored using T2*-weighted MRI. The purpose of this study is to investigate the relationship between the injected MPIO dose and the signal attenuation therefore to identify an optimal dose. This study will provide a valuable method to track inflammatory cells, which can be applied in either inflammation-related disease monitoring or drug development.