Rohan Dharmakumar1, Zhuoli Zhang1, Ioannis Koktzoglou2, Sotirios A. Tsaftaris1,3, Debiao Li1,4
1Radiology, Northwestern University, Chicago, IL, United States; 2Radiology, NorthShore University HealthSystem, Evanston, IL, United States; 3Electrical Engineering and Computer Science, Northwestern University, Evanston, IL, United States; 4Biomedical Engineering, Northwestern University, Evanston, IL, United States
Negative contrast methods utilizing local magnetic susceptibility shifting agents have become one of the most important approaches in cellular imaging research. However, visualizing and tracking labeled cells on the basis of negative contrast is often met with limited specificity and/or sensitivity. Here we report on a cellular MRI method that generates a new contrast with a distinct topology for identifying labeled cells permitting significant improvement in sensitivity and specificity.