Lyubov Ostrovska1, Mohammad Hedayati2, Christine Cornejo2, Yoshinori Kato1, Dmitri Artemov1, Theodore L. DeWeese2, Robert Ivkov2
1The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Department of Radiation Oncology & Molecular Radiation Sciences, The Johns Hopkins University School of Medicine
The goal of this study is to sensitize tumors to radiation therapy with heat generated by magnetic bionized nanoferrite (BNF)-nanoparticles within stem cells that home to hypoxic areas in tumors. Previously, we demonstrated that in mouse models of prostate cancer intravenously injected mesenchymal stem cells migrate to tumors, home to hypoxic areas, and participate in tumor neovasculogenesis. It was also demonstrated that heating of tumor-bearing mice injected with BNF-particles resulted in tumor size reduction and delayed tumor growth. We aim to develop methods for stem cell-based delivery of BNF-nanoparticles to hypoxic areas in tumors for hyperthermic sensitization to irradiation.