Chiao-Yun Chen1,2, Gin-Chung Liu3,4,
Deng-Chyang Wu5,6, Yun-Ming Wang7, Pei-I Liu8,
Ting-Jung Chen, 23, Twei-Shiun Jaw3,4, Yu-Ting Kuo3,4
1Department of Medical Imaging,
Kaohsiung Medical University Hospital , Kaohsiung, Taiwan; 2Kaohsiung
Medical University, Kaohsiung, Taiwan; 3Department of Medical
Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 4Kaohsiung
Medical University , Kaohsiung, Taiwan; 5 Division of Gastroenterology,
Department of Internal Medicine, Kaohsiung Medical University Hospital,
Kaohsiung, Taiwan; 6Department of Internal Medicine, Faculty of
Medicine, College of Medicine, Kaohsiung Medical University , Kaohsiung,
Taiwan; 7Department of Biological Science and Technology, National
Chiao Tung University, Hsinchu, Taiwan; 8Department of Radiology,
Pingtung Pao Chien Hospital, Pingtung, Taiwan
We
have successfully synthesized and characterized a novel iron-based MR
contrast agent, MnFe2O4-PEG, for labeling gastric stem cell, CS12, in vitro.
Its carcinogenetic potential was well preserved following MR contrast
labeling. In addition, tumor growth from the labeled CS12 cell and the T2*
effect can be efficiently detected over three weeks with in vivo MRI. We
believe that this molecular imaging technique may contribute further
understanding of carcinogenesis induced by gastric stem cell and it may be
also beneficial to help gene or cellular therapy in the future.