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Abstract #4199

In Vivo Tracking of Gastric Stem Cell by MRI Using a Newly Synthesized Iron-Based Contrast Agent, MnFe2O4-PEG

Chiao-Yun Chen1,2, Gin-Chung Liu3,4, Deng-Chyang Wu5,6, Yun-Ming Wang7, Pei-I Liu8, Ting-Jung Chen, 23, Twei-Shiun Jaw3,4, Yu-Ting Kuo3,4

1Department of Medical Imaging, Kaohsiung Medical University Hospital , Kaohsiung, Taiwan; 2Kaohsiung Medical University, Kaohsiung, Taiwan; 3Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 4Kaohsiung Medical University , Kaohsiung, Taiwan; 5 Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 6Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University , Kaohsiung, Taiwan; 7Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan; 8Department of Radiology, Pingtung Pao Chien Hospital, Pingtung, Taiwan

We have successfully synthesized and characterized a novel iron-based MR contrast agent, MnFe2O4-PEG, for labeling gastric stem cell, CS12, in vitro. Its carcinogenetic potential was well preserved following MR contrast labeling. In addition, tumor growth from the labeled CS12 cell and the T2* effect can be efficiently detected over three weeks with in vivo MRI. We believe that this molecular imaging technique may contribute further understanding of carcinogenesis induced by gastric stem cell and it may be also beneficial to help gene or cellular therapy in the future.