Taeho Kim1,2, Eric Momin3,
Jonghoon Choi1,4, Hasan Zaidi3, Jaeyun Kim1,2,
Mihyun Park2, Michael T. McMahon1,5, Taeghwan Hyeon2,
Alfredo Quinones-Hinojosa3, Jeff W. M. Bulte1, Assaf A.
Gilad1
1Department of Radiology, The Johns
Hopkins University School of Medicine, Baltimore, MD, United States; 2Chemical
& Biological Engineering, Seoul National University, Seoul, Korea,
Republic of; 3Department of Neurological Surgery, The Johns
Hopkins University School of Medicine, Baltimore, MD, United States; 4CSTL,
National Institute of Standards and Technology, Gaithersburg, MD, United
States; 5F. M. Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, MD, United States
New
MnO nanoparticles, which have "hollow" structures in a mesoporous
silica coating were designed and successfully synthesized. We have
demonstrated improved T1 and T2 contrast with these nanoparticles. These
nanoparticles showed high cellular uptake with the use of electroporation and
were detected with magnetic resonance imaging (MRI) both in vivo and in
vitro. Thus, these novel MnO nanoparticles represent an efficient alternative
to label and track transplanted cells with MRI.