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Abstract #4202

Detection of Spontaneously Occuring Amyloid Plaques in a Primate Model of Alzheimer's Disease

Anne Bertrand1, Adrien Pasquier1, Alexandra Petiet1,2, Christopher Wiggins2, Sebastien Meriaux2, Audrey Kraska1, Olene Dorieux1,3, Nelly Joseph-Mathurin1, Philippe Hantraye1, Fabienne Aujard3, Nadine Mestre-Frances4, Marc Dhenain1,2

1CEA, I2BM, MIRCen-URA2210, Fontenay aux Roses, France; 2CEA, I2BM, Neurospin, Gif-sur-Yvette, France; 3UMR CNRS/MNHN 7179, Brunoy, France; 4INSERM U710- EPHE- Universit Montpellier 2, Montpellier, France

Amyloid deposits are one of the characteristic lesions of Alzheimer's disease. Their sizes range from 50 m to 200 m. These lesions can be detected in transgenic mouse model of Alzheimer's disease by MRI, however, amyloid deposits in mice are very different than those occurring spontaneously in aged primates or humans with Alzheimer's disease. Here, we show that a protocol based on the staining of amyloid plaques with a non targeted Gadolinium contrast agent allows to detect spontaneously occurring amyloid plaques in aged mouse lemur Primates.