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Abstract #4214

Validation of Optical Tomography in Vivo

Yuting Lin1, Mehmet B. Unlu1, Brian Grimmond2, Anup Sood2, Egidijus E. Uzgiris3, David Thayer1, Han Yan1, Orhan Nalcioglu1, Gultekin Gulsen1

1Center for Functional Onco-Imaging, University of California, Irvine, CA, United States; 2GE Gobal Research, Niskayuna, NY, United States; 3Rensselaer Polytechnic Institute,, Troy, NY, United States

Multi-modality imaging is becoming a trend in developing new generation in vivo imaging techniques for diagnosis. Recently, our group has developed a high temporal resolution dynamic MRI/DOT multi-modality imaging system. In such a multi-modality system, each modality measures a different parameter set, which make it difficult to cross-validate the parameters measured by different modalities. An alternative solution is using a bi-functional contrast agent that provides contrast for both optical and MRI simultaneously. Here, our in vivo small animal study is the first to validate a true multi-modality system with a true multi-modality contrast agent.