Abstract #4215

Novel Cross-Linked Liposomal Chemical Saturation Transfer or CEST Agents

Aristarchos Papagiannaros¹, Valeria Righi^1,2, George Dai², A Aria Tzika^1,2

¹NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriners Burns Institute, Harvard Medical School, Boston, MA, United States; ²Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center of Biomedical Imaging, Boston, MA, United States

Liposomal CEST agents are a novel class of contrast agents that demonstrate excellent imaging capacity in phantoms and ex vivo, but their instability is preventing their use in imaging inflammation or cancer. We present cross-linked liposomal CEST agents that efficiently separated the bulk water from the intra-liposomal water signal, while offer increased stability for in vivo applications.