Prolonged and Homogenous Delivery of Gd Chelates to the Rat Brain with an Osmotic Pump

Paul A. Schornack¹

The purpose of this study is to demonstrate the very prolonged, chronic delivery of neutral & negatively charged Gd-chelates, in addition to the positively charged Mn2+ ion, directly to rat brain interstitium by direct infusion into CSF of the lateral ventricles using an osmostic pump. The main goal of this work is to develop a framework for delivering molecular imaging agents of interest, such as pH reporting agents, to the brain in a consistent & predictable manner.