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Abstract #4220

Prolonged and Homogenous Delivery of Gd Chelates to the Rat Brain with an Osmotic Pump

Paul A. Schornack1

1Radiology, University of Pittsburgh, Pittsburgh, PA, United States

The purpose of this study is to demonstrate the very prolonged, chronic delivery of neutral & negatively charged Gd-chelates, in addition to the positively charged Mn2+ ion, directly to rat brain interstitium by direct infusion into CSF of the lateral ventricles using an osmostic pump. The main goal of this work is to develop a framework for delivering molecular imaging agents of interest, such as pH reporting agents, to the brain in a consistent & predictable manner.