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Abstract #4219

On the Effect of Contrast Agent Internalization in a Two Compartment Diffusion Model

Thomas Kampf1, Christian Herbert Ziener1, Peter Michael Jakob1,2, Wolfgang Rudolf Bauer3

1Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany; 2Research Center for Magnetic Resonance Bavaria (MRB), Wuerzburg, Bavaria, Germany; 3Medical Clinic and Polyclinic 1, University of Wuerzburg, Wuerzburg, Bavaria, Germany

Contrast agents (CA) are commonly used to alter the contrast in MR data. Thus, profound knowledge of the CAs influence on the MR signal is important. In this work the effect of CA internalization is studied numerically. The simulations show that the simple linear relationship between the concentration of the CA and the relaxation rate is not preserved if the CA is internalized in a small part of the volume. This leads to a decreased apparent relaxivity. Furthermore an upper limit for the averaged relaxation rate was observed for a given volume fraction and size of the CA containing compartment.