Abstract #4218

Transition to MRI Guided Interventions: First Multimodal Embolization Particles Being Visible in MRI and X-Ray/CT

Snke H. Bartling¹, Johannes Budjan¹, Hagit Aviv², Henrik J. Michaely¹, Wolfhard Semmler³, Stefan O. Schnberg¹, Steffen Diehl¹, Shlomo Margel², Maliha Sadick¹

¹Clinical Radiology and Nuclear Medicine, University Medical Center, Mannheim, Baden-Wrttemberg, Germany; ²Dept. of Chemistry, Bar-Ilan University, Ramat-Gan, Israel; ³Dept. of Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany

MRI guidance of interventions is a goal. Current embolization particles cannot be detected by an imaging modality (clinical) or only by CT/X-ray (research). Here, we developed and tested the first multimodal embolization particles being visible within MRI and CT/x-ray. An animal model was used. Post embolization imaging confirmed dual-modality contrast as embolized areas could be detected by CT and MRI. Histology confirmed results. The particles consist of two clinically approved substances: polymerized Iodine and USPIO. Once introduced into clinical routine, improvements of embolization therapy can be expected, because both CT and MRI could be used for treatment control.