Abstract #4217

Controlled-Release and Magnetic Resonance Imaging of Doxorubicin-Conjugated Magnetic Nanoparticles from 3D Poly(Propylene Fumarate) Scaffolds

Jonghoon Choi^1,2, Kyobum Kim³, Taeho Kim⁴, Taeghwan Hyeon⁴, Mike T. McMahon¹, Jeff WM Bulte¹, John P. Fisher^3,5, Assaf A. Gilad¹

¹Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; ²Biochemical Science, National Institute of Standard and Technology, Gaithersburg, MD, United States; ³Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, United States; ⁴Chemical Engineering, Seoul National University, Seoul, Korea, Republic of; ⁵Fischell Department of Bioengineering, University of Maryland, College Park, MD, United States

Three-dimensional PPF (poly(propylene fumarate)) scaffolds carrying cancer drug-coated nanoparticles showed controlled release of drug nanoparticles and bimodal imaging (fluorescence and magnetic resonance) capabilities. This novel biopolymer matrix could be used for many biomedical applications, including MR-guided implantation, as a drug-carrying vehicle, and as a tumor treatment because of the persistent release of drugs in the vicinity of a malignancy.