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Abstract #4217

Controlled-Release and Magnetic Resonance Imaging of Doxorubicin-Conjugated Magnetic Nanoparticles from 3D Poly(Propylene Fumarate) Scaffolds

Jonghoon Choi1,2, Kyobum Kim3, Taeho Kim4, Taeghwan Hyeon4, Mike T. McMahon1, Jeff WM Bulte1, John P. Fisher3,5, Assaf A. Gilad1

1Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States; 2Biochemical Science, National Institute of Standard and Technology, Gaithersburg, MD, United States; 3Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, United States; 4Chemical Engineering, Seoul National University, Seoul, Korea, Republic of; 5Fischell Department of Bioengineering, University of Maryland, College Park, MD, United States

Three-dimensional PPF (poly(propylene fumarate)) scaffolds carrying cancer drug-coated nanoparticles showed controlled release of drug nanoparticles and bimodal imaging (fluorescence and magnetic resonance) capabilities. This novel biopolymer matrix could be used for many biomedical applications, including MR-guided implantation, as a drug-carrying vehicle, and as a tumor treatment because of the persistent release of drugs in the vicinity of a malignancy.