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Abstract #4225

Fluorinated Contrast Agents with Cation Depending T1 Sensitivity

Markus Plaumann1, Dieter Leibfritz1

1Institute of Organic Chemistry, University of Bremen, Bremen, Germany

The synthesis of metal ion sensitive MR-contrast agents is important for many medical studies, i.e. neuronal processes. Eight fluorinated Gd3+ complexes were synthesized to study the effect of different metal ions to the relaxation time. 1H-T1 measurements of the synthesized complexes show a strong dependence of relaxivity in presence of diamagnetic metal ions (i.e. Na+, K+, Ca2+, Mg2+) and additionally Mn+-concentration. Furthermore, relaxation times depend on temperature and pH-value. The molecular structure and length of the side chain of the synthesized complexes is very important for sensitivity to metal ions and changes in T1 times.