Markus Plaumann1, Dieter Leibfritz1
1Institute of Organic Chemistry,
University of Bremen, Bremen, Germany
The
synthesis of metal ion sensitive MR-contrast agents is important for many
medical studies, i.e. neuronal processes. Eight fluorinated Gd3+
complexes were synthesized to study the effect of different metal ions to the
relaxation time. 1H-T1 measurements of the synthesized
complexes show a strong dependence of relaxivity in presence of diamagnetic
metal ions (i.e. Na+, K+, Ca2+, Mg2+)
and additionally Mn+-concentration. Furthermore, relaxation times
depend on temperature and pH-value. The molecular structure and length of the
side chain of the synthesized complexes is very important for sensitivity to
metal ions and changes in T1 times.
Keywords