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Abstract #4226

Positive Contrast and Quantitative Imaging of Magnetic Nanoparticles and Cancer Cells with Biomarker Targeted RGD-Nanoparticle Conjugates Using T1 Weighted Ultrashort Echo Time (UTE) Imaging

Xiaodong Zhong1, Longjiang Zhang2,3, Liya Wang2, Hongwei Chen2, Julie Yeh2, Andrew Wang4, Hui Mao2

1MR R&D Collaborations, Siemens Healthcare, Atlanta, GA, United States; 2Department of Radiology, Center for Systems Imaging, Emory University, Atlanta, GA, United States; 3Department of Radiology, Jinling Hospital, Nanjing University College of Clinical Medicine, Nanjing, Jiangsu, China; 4Ocean NanoTech, LLC, Springdale, AR, United States

Negative contrast of magnetic nanoparticles (MNPs) on conventional T2 weighted images may suffer from poor contrast to noise ratio (CNR). This study demonstrated that positive T1 contrast from MNPs can be obtained using ultrashort echo time (UTE) imaging, resulting higher CNR than that of conventional T2 weighted imaging. Signal intensity of MNPs in UTE images has a linear correlation with core size and concentration of MNPs used in this study. Cell imaging with the UTE method also demonstrated potential applications of UTE imaging of biomarker targeted MNPs with contrast enhancement associated to the binding of cell targeted MNP.