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Abstract #4227

MR Lymphography with Fe3O4 Nanoparticles in Rabbits: In Vivo Investigation of Metabolism of Fe3O4 Nanoprobes

Rong Rong1, Wang Ruixue2, Wang Xiaoying1, Zhang Jue2, Song Yujun2

1Department of Radiology, 1st Hospital of Peking University, Beijing, China; 2Department of Biomedicine, Peking University, Beijing, China

The metabolism of magnetic nanoprobes for MRI was investigated in vivo in order to determinate optimized diagnosis time for the most contrast imaging and to discover nidus. After injection of these nanoprobes into rabbits, a significant darkening effect on the liver epithelial net lymph tissue was observed in 20 min, with about 20% reduce of the spin-spin relaxation time T2. The metabolism study on these nanoparticles indicated that they did not show any weak toxicity to organs detected and finally entered into the hematopoietic organ C spleen without obvious retention in any related organs after recycling for 3 days.