Rong Rong1, Wang Ruixue2, Wang
Xiaoying1, Zhang Jue2, Song Yujun2
1Department of Radiology, 1st Hospital
of Peking University, Beijing, China; 2Department of Biomedicine,
Peking University, Beijing, China
The
metabolism of magnetic nanoprobes for MRI was investigated in vivo in order
to determinate optimized diagnosis time for the most contrast imaging and to
discover nidus. After injection of these nanoprobes into rabbits, a
significant darkening effect on the liver epithelial net lymph tissue was
observed in 20 min, with about 20% reduce of the spin-spin relaxation time
T2. The metabolism study on these nanoparticles indicated that they did not
show any weak toxicity to organs detected and finally entered into the
hematopoietic organ C spleen without obvious retention in any related organs
after recycling for 3 days.
Keywords