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Abstract #4228

Ultrasmall Particle of Iron Oxide RGD Peptidomimetic Conjugate as Novel MRI Contrast Agent

Sophie Laurent1, Carmen Burta1, Vincent Rerat2, Jacqueline Marchand-Brynaert2, Luce Vander Elst1, Robert N. Muller1

1Universit de Mons, Mons, Belgium; 2Universit catholique de Louvain, Louvain-la-Neuve , Belgium

In this work, we describe the grafting of a home-made RGD peptidomimetic on ultrasmall particles of iron oxide (USPIO) coated with 3,3-bis(phosphonate)propionic acid, and the determination of the grafting rates by X-ray photoelectron spectroscopy (XPS). The USPIO-g-Mimic have been characterized by photon correlation spectroscopy (PCS); their magnetometric and relaxometric profiles, and their capacity to target leukemic cells were also analyzed.