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Abstract #4257

2D L-COSY MR Spectroscopy Detects Very Early Changes in the Brain of Alzheimer Mouse

S van Duijn1, F Kara2, N Braakman2,3, S G. van Duinen1, R Natt1, M A. van Buchem4, A Alia2

1Department of Pathology, Leiden University Medical Center, Leiden, Netherlands; 2Leiden Institute of Chemistry, Leiden University, Leiden, Netherlands; 3Catharina hospital, Eindhoven, Netherlands; 4Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Proton magnetic resonance spectroscopy (MRS) provides a non-invasive way to investigate in vivo neurochemical abnormalities of many brain disorders. However, its role in finding very early and specific metabolic changes as biomarkers for Alzheimers disease (AD) has not yet been established. In the present study we employed, for the first time, localized 2D L-COSY MRS in young wild-type and transgenic APP/PS1 mouse model of AD to probe specific early metabolic changes during AD. Our results provide an important indication of early neurochemical changes that take place before A plaque formation in these transgenic mice.