S van Duijn1,
F Kara2, N Braakman2,3, S G. van Duinen1, R
Natt1, M A. van Buchem4, A Alia2
1Department of Pathology, Leiden
University Medical Center, Leiden, Netherlands; 2Leiden Institute
of Chemistry, Leiden University, Leiden, Netherlands; 3Catharina
hospital, Eindhoven, Netherlands; 4Department of Radiology, Leiden
University Medical Center, Leiden, Netherlands
Proton
magnetic resonance spectroscopy (MRS) provides a non-invasive way to
investigate in vivo neurochemical abnormalities of many brain disorders.
However, its role in finding very early and specific metabolic changes as
biomarkers for Alzheimers disease (AD) has not yet been established. In the
present study we employed, for the first time, localized 2D L-COSY MRS in
young wild-type and transgenic APP/PS1 mouse model of AD to probe specific
early metabolic changes during AD. Our results provide an important
indication of early neurochemical changes that take place before A plaque
formation in these transgenic mice.