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Abstract #4258

Echo Planar Spectroscopic Imaging in Patients with Amyotrophic Lateral Sclerosis

Sanjeev Chawla1, Sumei Wang1, Sulaiman Sheriff2, John H. Woo1, Lauren Elman3, Leo F. McCluskey3, Murray Grossman3, Elias R. Melhem1, Andrew Maudsley2, Harish Poptani1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Radiology, University of Miami, Miami, FL, United States; 3Neurology, University of Pennsylvania, Philadelphia, PA, United States

The purpose of this study was to evaluate the potential of echoplanar spectroscopic imaging (EPSI) in assessing metabolic alterations beyond the motor cortex of ALS patients. NAA/Cr and Cho/Cr were measured from the precentral gyrus (PreCG), postcentral gyrus (postCG) and internal capsule (IC) and compared to Occipital region (OR) as an internal control. Significant reductions in NAA/Cr were observed from the preCG and IC from both the hemispheres. Significantly higher Cho/Cr ratios were also observed from the preCG, postCG and IC regions indicating that metabolic abnormalities in ALS extend beyond the motor cortex that can be observed using EPSI.